New Function of VEGF Receptor Isoform and Microdomain in Podocytes
نویسندگان
چکیده
منابع مشابه
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BACKGROUND Both, increased plasma concentrations of vascular endothelial growth factor (VEGF) and increased expression of transient receptor potential canonical type 6 (TRPC6) channels in podocytes have been associated with proteinuric kidney diseases. Now, we investigated the hypothesis that VEGF regulates TRPC6 in podocytes. METHODS TRPC6 messenger RNA (mRNA) and TRPC6 protein expression we...
متن کاملHIV-1 upregulates VEGF in podocytes.
HIV-associated nephropathy (HIVAN) is characterized by collapsing FSGS. Because transgenic mice with podocyte-specific overexpression of the vascular endothelial growth factor 164 (VEGF164) isoform also develop collapsing FSGS, we sought to determine whether VEGF plays a role in HIVAN. Compared with controls, immunohistochemistry revealed that kidneys from HIV-1-transgenic mice (Tg26) and from ...
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ژورنال
عنوان ژورنال: Trends in Glycoscience and Glycotechnology
سال: 2014
ISSN: 0915-7352,1883-2113
DOI: 10.4052/tigg.26.37